Authors - April L. Macasieb-Gumnad, Roberto M. Arguelles Abstract - The study focuses on transformational leadership, entrepreneurship, and sustainability in higher education. Using Saint Louis University (Philippines) as a case study, the purpose was to (1) identify the role transformational leadership has in developing (or affecting) the characteristics of an entrepreneurial university, (2) identify how transformational leadership fosters sustainable innovation, and (3) assess the effect entrepreneurial university characteristics have on achieving sustainable outcomes. This quantitative research used three different instruments that were previously validated (HEInnovate Questionnaire; Sustainability Assessment Questionnaire; and Survey of Transformational Leadership) to gather data from a sample of 795 respondents at SLU and analyzed the resulting data using Spearman-rank correlation analysis and simple linear regression. This study provided practical applications to the literature on higher education management through empirical evidence of relationships between types of leadership styles, achievement of SDGs, organizational structures/models/characteristics, and sustainability of innovation in higher educations.The SLU CARES Innovation Framework was proposed to provide actionable insights for academic and administrative leaders seeking to align Catholic educational missions with contemporary demands for innovation and sustainability.